HIV Protease
HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).
HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.
All Product Categories
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HIV Protease Related Products (203)
Related Products (203)
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Indinavir-13C4,15N
0 ImagesCat. No.: HY-B0689S1Synonyms: MK-639 free base-13C4,15N; L-735524 free base-13C4,15NIndinavir-13C4,15N (MK-639 (free base)-13C4,15N) is 13C and 15N labeled Indinavir. Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor.
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CI-1029
0 ImagesCat. No.: HY-114957CAS No.: 207736-05-8CI-1029 is a HIV-1 protease inhibitor with a human IC50 of 0.11 nM. CI-1029 inhibits both wild-type and mutant HIV proteases, and exhibits antiviral activity against HIV and multiple drug-resistant HIV strains, with an EC50 of 6.31 μM in the presence of 30% human serum. CI-1029 can be used in studies related to HIV infection and acquired immunodeficiency syndrome (AIDS).
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Saquinavir-13C6
0 ImagesCat. No.: HY-17007S2Synonyms: Ro 31-8959-13C6Saquinavir-13C6 (Ro 31-8959-13C6) is 13C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
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GRL-07524
0 ImagesCat. No.: HY-175031GRL-07524 (Compound 4e) is a potent inhibitor of HIV-1 protease (Ki = 0.22 nM). GRL-07524 contains oxaspirocyclic carbamates as the P2 ligands. GRL-07524 exhibits good antiviral activity with an EC50 = 210 nM. GRL-07524 binds to the HIV-1 PR active site in one of the four symmetry independent molecules along with key catalytic residues.
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Hinokinin (Standard)
0 ImagesCat. No.: HY-N10420RCAS No.: 26543-89-5Synonyms: (-)-Hinokinin (Standard)Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme.
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LY-289612
0 ImagesCat. No.: HY-135459CAS No.: 148314-61-8LY-289612 is a HIV-1 protease inhibitor, with an IC50 of 1.5 nM.
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Atazanavir (Standard)
0 ImagesSynonyms: BMS-232632 (Standard)Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death.
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PL-100
0 ImagesCat. No.: HY-107468CAS No.: 612547-11-2PL-100 is a potent HIV-1 protease inhibitor with a Ki of 36 pM and an EC50 of 16 nM. PL-100 inhibits viral replication by suppressing HIV-1 protease activity and demonstrates excellent antiviral efficacy against drug-resistant HIV strains. PL-100 can be used in research on drug-resistant HIV disease.
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Amprenavir-13C6
0 ImagesCat. No.: HY-17430S2Synonyms: VX-478-13C6
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U 92163
0 ImagesCat. No.: HY-187623CAS No.: 149607-21-6U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS).
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Caspase-3-IN-2
0 ImagesCat. No.: HY-W415273CAS No.: 62252-25-9
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Nelfinavir Mesylate (Standard)
0 ImagesSynonyms: AG 1343 Mesylate (Standard)Nelfinavir (Mesylate) (Standard) is the analytical standard of Nelfinavir (Mesylate). This product is intended for research and analytical applications. Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent.
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LY-326188
0 ImagesCat. No.: HY-116048CAS No.: 169168-35-8
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Mozenavir dimethanesulfonate
0 ImagesCat. No.: HY-105148ACAS No.: 177932-89-7Synonyms: DMP-450 dimethanesulfonateMozenavir dimethanesulfonate (DMP-450 dimethanesulfonate) is an orally active cyclic urea HIV-1 protease inhibitor with an IC50 of 76 nM. Mozenavir dimethanesulfonate inhibits replication by targeting viral protease, blocks viral polyprotein processing, and induces the production of core-uncondensed, immature, non-infectious viral particles in chronically infected cells. Mozenavir dimethanesulfonate is applicable to research related to HIV infection.
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SRI-32743
0 ImagesCat. No.: HY-175535CAS No.: 1940118-42-2SRI-32743 is an allosteric human dopamine transporter (hDAT) modulator (IC50=9.86 μM). SRI-32743 is promising for research of HIV-Tat-induced neurotoxicity.
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HIV-1 protease-IN-15
0 ImagesCat. No.: HY-174998CAS No.: 2986573-09-3
